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ROS are unstable oxygen-containing molecules that easily react with other molecules in a cell [14] and are generated after physiological dysfunctions or exposure to physical agents, such as ultraviolet rays and heat, chemical factors, environmental toxicants, smoking, alcohol, or even other factors, such as obesity, varicocele, aging, or diabetes [11]

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This review discusses the role of GPx-1 in these diseases and speculates on potential future therapies to harness the beneficial effects of this ubiquitous antioxidant enzyme